Detaillierte Beitrags-Information
| Beitragstitel | Pain Thresholds in Patients with Migraine assessed by Quantitative Sensory Testing |
|---|---|
| Beitragscode | P22 |
| Autor:innen | |
| Präsentationsform | Freie Mitteilung + Poster |
| Themengebiete |
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| Abstract-Text |
Background: In migraine, cutaneous allodynia and hyperalgesia are described, indicating central sensitization. However, quantitative sensory testing (QST) findings vary widely among studies, stimuli and locations. Moreover, it is unclear if these symptoms might be predictors of treatment response, with conflicting evidence in previous literature. Our aim is to characterize the somatosensory profile in migraine and its potential role in predicting response to calcitonin gene-related peptide (CGRP)-antibodies, after 6 months. Materials and Methods: In our prospective, ongoing study, patients with migraine (according to ICHD-3) and ≥8 monthly headache days are included. QST was performed on the day of treatment initiation with CGRP-antibodies, according to a standardized protocol on the hand and face. Pain thresholds for: i) cold, ii) heat, iii) mechanical(pinprick-) and iv) pressure stimuli, as well as v) mechanical pain sensitivity and vi) dynamic mechanical allodynia (DMA) were measured. The 12-item Allodynia Symptom Checklist (ASC-12) was also performed. Results: We present preliminary results from 26 patients that underwent QST at study-baseline (20 women, age 41.8±14 years, 16 with chronic migraine, 5 with aura). All patients had at least one abnormal QST-finding, 21 (81%) on both face and hand, 3 (11.5%) only on the face and 2 (7.5%) only on the hand. Decreased pressure pain threshold was the most common abnormal finding (20/26=77% on the face, 13/26=50% on the hand), followed by DMA to light touch (15/26=58% on the face and 14/26=54% on the hand). 14/26 patients had allodynia according to the ASC-12. Mechanical pain threshold (MPT) was less frequently abnormal (4/26 in the hand; 1/26 in the face), but was significantly associated with Allodynia by ASC-12 score (MPT hand: Spearmans-Rho=-0.501, p=0.015). Currently, we have 6-month-follow-up data from 16 patients (9/16 responders); in a preliminary analysis, we did not find any associations between QST parameters and treatment-response. Conclusion: Our data suggest that QST abnormalities are very common in patients with frequent migraine, not only in the trigeminal area, but also on the hand. Pressure hyperalgesia and allodynia to light touch are the most common abnormalities. The value of QST in predicting treatment response to CGRP-antibodies is still under investigation. |